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Hiroshi Takayanagi Selected Research

Denosumab

1/2019Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis.
10/2017RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

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Hiroshi Takayanagi Research Topics

Disease

17Bone Resorption
09/2023 - 05/2002
15Arthritis (Polyarthritis)
09/2023 - 06/2003
12Inflammation (Inflammations)
09/2023 - 12/2005
8Osteoporosis
03/2015 - 08/2005
7Rheumatoid Arthritis
01/2023 - 01/2007
6Autoimmune Diseases (Autoimmune Disease)
01/2019 - 02/2008
5Experimental Arthritis
09/2023 - 02/2008
4Neoplasms (Cancer)
01/2020 - 02/2010
3Osteopetrosis
03/2008 - 04/2004
2Communicable Diseases (Infectious Diseases)
02/2024 - 01/2018
2Metabolic Bone Diseases (Osteopenia)
09/2023 - 03/2012
2Immune System Diseases (Immune Disorders)
01/2023 - 01/2019
2Neoplasm Metastasis (Metastasis)
01/2020 - 01/2019
2Bone Diseases (Bone Disease)
03/2014 - 12/2005
2Rheumatic Diseases (Rheumatism)
12/2009 - 05/2009
1Periodontitis
02/2024
1Frailty
08/2022
1Hip Dislocation
01/2022
1Juvenile Arthritis (Juvenile Idiopathic Arthritis)
01/2021
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2021
1Osteomyelitis
01/2021
1Hypertrophy
08/2020
1Necrosis
06/2020
1Carcinogenesis
01/2019
1Breast Neoplasms (Breast Cancer)
01/2019
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
01/2019
1Osteolysis
01/2019
1Lung Neoplasms (Lung Cancer)
10/2017
1Osteosarcoma (Osteogenic Sarcoma)
01/2017
1Bone Fractures (Bone Fracture)
03/2016
1Hypergammaglobulinemia (Hyperimmunoglobulinemia)
03/2015
1Infertility (Sterility)
05/2014
1Cleidocranial Dysplasia (Cleidocranial Dysostosis)
01/2014
1Mitochondrial Diseases (Mitochondrial Disease)
11/2012
1Joint Diseases (Joint Disease)
05/2012
1Vitamin E Deficiency
03/2012

Drug/Important Bio-Agent (IBA)

14CytokinesIBA
02/2024 - 12/2005
13LigandsIBA
02/2024 - 01/2005
6Proteins (Proteins, Gene)FDA Link
01/2021 - 04/2004
4Interleukin-17 (Interleukin 17)IBA
01/2021 - 01/2012
4Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA
03/2009 - 01/2005
3CollagenIBA
01/2023 - 01/2014
3RANK LigandIBA
01/2022 - 12/2005
3Phosphotransferases (Kinase)IBA
01/2020 - 03/2008
3Semaphorin-3AIBA
01/2019 - 05/2012
3Antirheumatic Agents (DMARD)IBA
12/2009 - 01/2007
2RNA (Ribonucleic Acid)IBA
02/2024 - 01/2017
2Immunologic Factors (Immunomodulators)IBA
01/2023 - 12/2015
2Interleukin-6 (Interleukin 6)IBA
01/2022 - 02/2010
2AutoantibodiesIBA
08/2020 - 03/2015
2Immunoglobulin G (IgG)IBA
01/2019 - 03/2015
2DenosumabFDA Link
01/2019 - 10/2017
2PlasticsIBA
01/2015 - 01/2014
2AntigensIBA
01/2015 - 01/2014
2InterleukinsIBA
04/2010 - 11/2006
2Fc Receptors (Fc Receptor)IBA
07/2007 - 04/2004
1Oncostatin MIBA
02/2024
1Janus KinasesIBA
09/2023
1Janus Kinase InhibitorsIBA
09/2023
1Peptides (Polypeptides)IBA
01/2023
1Matrix Metalloproteinases (MMPs)IBA
01/2022
1PeriostinIBA
01/2022
1Interleukin-4 (Interleukin 4)IBA
01/2021
1Interleukin-18 (Interleukin 18)IBA
01/2021
1Collagen Type II (Type II Collagen)IBA
08/2020
1Butyrates (Butyrate)IBA
08/2020
1chlorine dioxide (Alcide)IBA
06/2020
1Proto-Oncogene Proteins c-hckIBA
01/2020
1tyrosine receptor (receptor, tyrosine)IBA
01/2020
1Stromal Interaction MoleculesIBA
01/2019
1Chemotactic FactorsIBA
01/2019
1Immunoglobulin E (IgE)IBA
01/2019
1Gonadal Steroid Hormones (Sex Hormones)IBA
10/2017
1FollistatinIBA
01/2017
1Carrier Proteins (Binding Protein)IBA
01/2017
1AntibodiesIBA
12/2015
1Hormones (Hormone)IBA
09/2015
1ChemokinesIBA
09/2015
1Antigen-Antibody Complex (Immune Complex)IBA
03/2015
1theaflavin-3,3'-digallateIBA
03/2015
1EndotoxinsIBA
05/2014
1ibrutinibIBA
03/2014
1Transcription Factors (Transcription Factor)IBA
01/2014
1Class Ia Phosphatidylinositol 3-KinaseIBA
12/2012
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
12/2012
1bone resorption factorIBA
11/2012
1Adenosine Triphosphate (ATP)IBA
11/2012
1Mitochondrial DNA (mtDNA)IBA
11/2012
1MineralsIBA
11/2012
1CD100 antigenIBA
11/2012
1OsteoprotegerinIBA
05/2012
1CateninsIBA
03/2012
1Tocopherols (Tocopherol)IBA
03/2012
1Tissue Plasminogen Activator (Alteplase)FDA Link
03/2012
1ThiazolidinedionesIBA
10/2010

Therapy/Procedure

2Therapeutics
07/2007 - 06/2003
1Exercise Therapy (Therapy, Exercise)
08/2022
1Disarticulation
01/2022
1Drug Therapy (Chemotherapy)
11/2019
1Oral Administration
01/2019